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1.
Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo-hallucinations.
Br J Clin Pharmacol;
90(1): 321-335, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37724688
2.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord;
38(3): 386-398, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36807624
3.
Dealing with doping. A plea for better science, governance and education.
Br J Clin Pharmacol;
88(2): 566-578, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34291479
4.
Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double-blind, placebo-controlled, cross-over study.
Br J Clin Pharmacol;
88(6): 2926-2937, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35028950
5.
Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders.
Int J Mol Sci;
22(4)2021 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33562713
6.
Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes.
Eur J Appl Physiol;
120(8): 1893-1904, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32537688
7.
Futility of current urine salbutamol doping control.
Br J Clin Pharmacol;
84(8): 1830-1838, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29722428
8.
In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms.
J Antimicrob Chemother;
71(7): 1866-80, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27107096
9.
Good Clinical Trials by removing defensive interpretation of Good Clinical Practice guidelines.
Br J Clin Pharmacol;
87(12): 4552-4559, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33939192
10.
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.
Sci Transl Med;
16(739): eadk9109, 2024 Mar 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38507469
11.
Erythropoietin doping in cycling: lack of evidence for efficacy and a negative risk-benefit.
Br J Clin Pharmacol;
75(6): 1406-21, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23216370
12.
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.
Clin Transl Sci;
16(8): 1408-1420, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37177855
13.
Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double-blind placebo-controlled cross-over study.
Clin Transl Sci;
15(12): 2971-2981, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36281627
14.
Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients.
PLoS One;
17(1): e0256752, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35085249
15.
Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
Clin Pharmacol Ther;
112(5): 1008-1019, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35762293
16.
Acute retigabine-induced effects on myelinated motor axons in amyotrophic lateral sclerosis.
Pharmacol Res Perspect;
10(4): e00983, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35881020
17.
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Clin Transl Sci;
15(8): 2010-2023, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35649245
18.
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.
Nat Commun;
12(1): 7334, 2021 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34921133
19.
Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation.
Transl Psychiatry;
11(1): 325, 2021 05 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34045439
20.
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Clin Pharmacol Ther;
107(2): 406-414, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31437302